STUDIES & PUBLICATIONS

“Publish or perish” is a well-known phrase among scientists. In other words, an important part of research is the publication of one's own scientific findings within the scientific community. On the one hand, this serves to provide information about scientific progress, so that others can continue their research based on the latest findings. On the other hand, publishing your work, especially in scientific journals, is a way to ensure the quality of your work and to build a relationship with the scientific community. Scientific journals only publish articles that have passed a critical review by recognized experts (“peer-reviewed”). For decades, Beiersdorf has published its research results in high-quality, recognized scientific journals as well as in the form of lectures and posters at congresses, thus opening itself up to the critical opinion of the scientific community. The following is an overview of the peer-reviewed publications of Beiersdorf's scientists. They impressively underscore the importance of our global research and development work.

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325 Publications

2024

Frontiers in Aging Sec. Genetics, Genomics and Epigenomics of Aging, January 2024

Development of an epigenetic clock to predict visual age progression of human skin

Bienkowska A et. al.

Frontiers in Aging Sec. Genetics, Genomics and Epigenomics of Aging, March 2024

Identification of dihydromyricetin as a natural DNA methylation inhibitor with rejuvenating activity in human skin.

Falckenhayn et. al.

Experimental Dermatology (2024), Exp Dermatol, 33: e70005. 2024

Skin Rejuvenation by Modulation of DNA Methylation

Grönniger, E., Max, H., Lyko, F. 

2023

Frontiers in Pharmacology 2023

Prediction of in vivo prenatal chlorpyrifos exposure leading to developmental neurotoxicity in humans based on in vitro toxicity data by quantitative in vitro-in vivo extrapolation

Algharably EA, Di Consiglio E, Testai E, Pistollato F, Bal-Price A, Najjar A, Kreutz R, Gundert-Remy U.

Journal of Applied Toxicology 2023

Suitability of different reconstructed human skin models in the skin and liver Chip2 microphysiological model to investigate the kinetics and first-pass skin metabolism of the hair dye, 4-amino-2-hydroxytoluene

Brandmair K, Tao TP, Gerlach S, Przibilla J, Schepky A, Marx U, Hewitt NJ, Kühnl J, Maschmeyer I.

International Journal of Cosmetic Science 2023

N-acetyl-L-hydroxyproline - A potent skin anti-ageing active preventing advanced glycation end-product formation in vitro and ex vivo

Knoblich C, Dunckelmann K, Krüger A, Küper T, Blatt T, Weise JM.

Archives of Toxicology 2023

Practical application of the interim internal threshold of toxicological concern (iTTC): a case study based on clinical data Najjar A, Ellison CA, Gregoire S, Hewitt NJ.

Najjar A, Ellison CA, Gregoire S, Hewitt NJ.

Frontiers in Pharmacology 2023

Editorial: Advances in and applications of predictive toxicology: 2022

Najjar A, Kramer N, Gardner I, Hartung T, Steger-Hartmann T.

Archives of Toxicology 2023

Evaluation of new alternative methods for the identification of estrogenic, androgenic and steroidogenic effects: a comparative in vitro/in silico study

Najjar A, Wilm A, Meinhardt J, Mueller N, Boettcher M, Ebmeyer J, Schepky A, Lange D.

Food and Chemical Toxicology 2023

Application habits and practices of regular sunscreen users in the United States: Results of an online survey

Norman KG, Loretz L, Kowcz A, Kaufman LE, Ruvolo E, Traudt M, Santos I, RoseMansfield R, Nash JF.

British Journal of Dermatology 2023

Less confident, successful and happy: patients with post-acne hyperpigmentation are stigmatized

Schuster B, Gallinger J, Philipp-Dormston WG, Vasel M, Layton AM.

Journal of Applied Toxicology 2023

Application of a skin and liver Chip2 microphysiological model to investigate the route-dependent toxicokinetics and toxicodynamics of consumer-relevant doses of genistein

Tao TP, Brandmair K, Gerlach S, Przibilla J, Schepky A, Marx U, Hewitt NJ, Maschmeyer I, Kühnl J.

Frontiers in Pharmacology 2023

Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions

Tao TP, Maschmeyer I, LeCluyse EL, Rogers E, Brandmair K, Gerlach S, Przibilla J, Kern F, Genies C, Jacques C, Najjar A, Schepky A, Marx U, Kühnl J, Hewitt NJ.

Regulatory Toxicology and Pharmacology 2023

From worst-case to reality - Case studies illustrating tiered refinement of consumer exposure to cosmetic ingredients

Tozer S, Alexander-White C, Amin R, Audebert F, Barratt C, O'Brien J, Burke T, Bury D, Nguea HD, Dimopoulou M, Farahmand S, Fritz S, Gerber E, Giusti A, Goodwin W, Kirsch T, Oreffo V, McNamara C.

Experimental Dermatology 2023

Ageing is associated with a reduction in markers of mitochondrial energy metabolism in the human epidermis

Vidali S, Feichtinger RG, Emberger M, Brunner SM, Gaisbauer S, Blatt T, Smiles WJ, Kreutzer C, Weise JM, Kofler B.

2022

Communications Biology 2022

Interference and co-existence of staphylococci and Cutibacterium acnes within the healthy human skin microbiome

Ahle CM, Stødkilde K, Poehlein A, Bömeke M, Streit WR, Wenck H, Reuter JH, Hüpeden J, Brüggemann H.

Frontiers in Genetics 2022

Single-Cell RNA Profiling of Human Skin Reveals Age-Related Loss of Dermal Sheath Cells and Their Contribution to a Juvenile Phenotype

Ahlers JMD, Falckenhayn C, Holzscheck N, Solé-Boldo L, Schütz S, Wenck H, Winnefeld M, Lyko F, Grönniger E, Siracusa A.

Regulatory Toxicology and Pharmacology 2022

A 10-step framework for use of read-across (RAX) in next generation risk assessment (NGRA) for cosmetics safety assessment

Alexander-White C, Bury D, Cronin M, Dent M, Hack E, Hewitt NJ, Kenna G, Naciff J, Ouedraogo G, Schepky A, Mahony C, Europe C.

Skin Pharmacology and Physiology 2022

A Biomimetic Combination of Actives Enhances Skin Hydration and Barrier Function via Modulation of Gene Expression: Results of Two Double-Blind, Vehicle-Controlled Clinical Studies

Altgilbers S, Rippke F, Filbry A, Conzelmann S, Vietzke JP, Burkhardt T, Segger D, Roggenkamp D, Grönniger E.

International Journal of Cosmetic Science 2022

Multidirectional activity of bakuchiol against cellular mechanisms of facial ageing - Experimental evidence for a holistic treatment approach

Bluemke A, Ring AP, Immeyer J, Hoff A, Eisenberg T, Gerwat W, Meyer F, Breitkreutz S, Klinger LM, Brandner JM, Sandig G, Seifert M, Segger D, Rippke F, Schweiger D.

Toxicology Research 2022

Assessment of dermal absorption of aluminium from a representative antiperspirant formulation using a ((26)Al)Al microtracer approach: a follow-up study in humans

de Ligt R, Westerhout J, Grossouw D, Buters TP, Rissmann R, Burggraaf J, Windhorst AD, Tozer S, Pappa G, Wall B, Bury D, Mason DR, Vaes WHJ.

NAR Genomics and Bioinformatics 2022

Inter-layer and inter-subject variability of diurnal gene expression in human skin

Del Olmo M, Spörl F, Korge S, Jürchott K, Felten M, Grudziecki A, de Zeeuw J, Nowozin C, Reuter H, Blatt T, Herzel H, Kunz D, Kramer A, Ananthasubramaniam B.

Skin Research and Technology 2022

Depth-dependent hydration dynamics in human skin: Vehicle-controlled efficacy assessment of a functional 10% urea plus NMF moisturizer by near-infrared confocal spectroscopic imaging (KOSIM IR) and capacitance method complemented by volunteer perception

Gallinger J, Kuhn A, Wessel S, Behm P, Heinecke S, Filbry A, Hillemann L, Rippke F.

Journal of Investigative Dermatology 2022

Macrophages Are Polarized toward an Inflammatory Phenotype by their Aged Microenvironment in the Human Skin

Gather L, Nath N, Falckenhayn C, Oterino-Sogo S, Bosch T, Wenck H, Winnefeld M, Grönniger E, Simm S, Siracusa A.

Journal of Pharmaceutical Sciences 2022

A Mechanistic Bayesian Inferential Workflow for Estimation of In Vivo Skin Permeation from In Vitro Measurements

Hamadeh A, Troutman J, Najjar A, Edginton A.

Regulatory Toxicology and Pharmacology 2022

Use of in vitro metabolism and biokinetics assays to refine predicted in vivo and in vitro internal exposure to the cosmetic ingredient, phenoxyethanol, for use in risk assessment

Hewitt NJ, Troutman J, Przibilla J, Schepky A, Ouédraogo G, Mahony C, Kenna G, Varçin M, Dent MP; Cosmetics Europe. Electronic address: cosmeticseurope@cosmeticseurope.eu.

Regulatory Toxicology and Pharmacology 2022

Expansion of the Cosmetics Europe skin sensitisation database with new substances and PPRA data

Hoffmann S, Alépée N, Gilmour N, Kern PS, van Vliet E, Boislève F, Bury D, Cloudet E, Klaric M, Kühnl J, Lalko JF, Mewes K, Miyazawa M, Nishida H, Tam Brami MT, Varçin M, Api AM, Europe C.

Journal of the American Academy of Dermatology 2022

Impact of visible light on skin health: The role of antioxidants and free radical quenchers in skin protection

Lim HW, Kohli I, Ruvolo E, Kolbe L, Hamzavi IH.

Photochemistry and Photobiology 2022

Mitigating Visible Light and Long Wavelength UVA1-induced Effects with Topical Antioxidants

Lyons AB, Zubair R, Kohli I, Nahhas AF, Braunberger TL, Mokhtari M, Ruvolo E, Lim HW, Hamzavi IH.

Frontiers in Molecular Neuroscience 2022

In vitro models for investigating itch

Mießner H, Seidel J, Smith ESJ.

Archives of Toxicology 2022

Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment

Najjar A, Punt A, Wambaugh J, Paini A, Ellison C, Fragki S, Bianchi E, Zhang F, Westerhout J, Mueller D, Li H, Shi Q, Gant TW, Botham P, Bars R, Piersma A, van Ravenzwaay B, Kramer NI.

Frontiers in Pharmacology 2022

Use of Physiologically-Based Kinetics Modelling to Reliably Predict Internal Concentrations of the UV Filter, Homosalate, After Repeated Oral and Topical Application

Najjar A, Schepky A, Krueger CT, Dent M, Cable S, Li H, Grégoire S, Roussel L, Noel-Voisin A, Hewitt NJ, Cardamone E.

Regulatory Toxicology and Pharmacology 2022

Read-across and new approach methodologies applied in a 10-step framework for cosmetics safety assessment - A case study with parabens

Ouedraogo G, Alexander-White C, Bury D, Clewell HJ 3rd, Cronin M, Cull T, Dent M, Desprez B, Detroyer A, Ellison C, Giammanco S, Hack E, Hewitt NJ, Kenna G, Klaric M, Kreiling R, Lester C, Mahony C, Mombelli E, Naciff J, O'Brien J, Schepky A, Tozer S, van der Burg B, van Vugt-Lussenburg B, Stuard S, Cosmetics Europe.

Journal of the American Academy of Dermatology 2022

Photoprotection for all: Current gaps and opportunities

Rigel DS, Lim HW, Draelos ZD, Weber TM, Taylor SC.

International Journal of Cosmetic Science 2022

Evaluation of efficacy of antioxidant-enriched sunscreen prodcuts against long wavelength ultraviolet A1 and visible light

Ruvolo E, Boothby-Shoemaker W, Kumar N, Hamzavi IH, Lim HW, Kohli I.

Antioxidants 2022

Assessing Cellular Uptake of Exogenous Coenzyme Q(10) into Human Skin Cells by X-ray Fluorescence Imaging

Staufer T, Schulze ML, Schmutzler O, Körnig C, Welge V, Burkhardt T, Vietzke JP, Vogelsang A, Weise JM, Blatt T, Dabrowski O, Falkenberg G, Brückner D, Sanchez-Cano C, Grüner F.

International Journal of Epidemiology 2022

Cohort Profile Update: The Study of Health in Pomerania (SHIP)

Völzke H, Schössow J, Schmidt CO, Jürgens C, Richter A, Werner A, Werner N, Radke D, Teumer A, Ittermann T, Schauer B, Henck V, Friedrich N, Hannemann A, Winter T, Nauck M, Dörr M, Bahls M, Felix SB, Stubbe B, Ewert R, Frost F, Lerch MM, Grabe HJ, Bülow R, Otto M, Hosten N, Rathmann W, Schminke U, Großjohann R, Tost F, Homuth G, Völker U, Weiss S, Holtfreter S, Bröker BM, Zimmermann K, Kaderali L, Winnefeld M, Kristof B, Berger K, Samietz S, Schwahn C, Holtfreter B, Biffar R, Kindler S, Wittfeld K, Hoffmann W, Kocher T.

Journal of Dermatological Treatment 2022

Exploring the burden of xerosis cutis and the impact of dermatological skin care from patient's perspective

von Stülpnagel CC, Augustin M, da Silva N, Schmidt L, Nippel G, Sommer R.

2021

Toxicology in Vitro 2021

Overall performance of Bovine Corneal Opacity and Permeability (BCOP) Laser Light-Based Opacitometer (LLBO) test method with regard to solid and liquid chemicals testing

Adriaens E, Verstraelen S, Desprez B, Alépée N, Abo T, Bagley D, Hibatallah J, Mewes KR, Pfannenbecker U, Van Rompay AR.

BMC Microbiology 2021

Comparison of three amplicon sequencing approaches to determine staphylococcal populations on human skin

Ahle CM, Stødkilde-Jørgensen K, Poehlein A, Streit WR, Hüpeden J, Brüggemann H.

Regulatory Toxicology and Pharmacology 2021

New framework for a non-animal approach adequately assures the safety of cosmetic ingredients - A case study on caffeine

Bury D, Alexander-White C, Clewell HJ 3rd, Cronin M, Desprez B, Detroyer A, Efremenko A, Firman J, Hack E, Hewitt NJ, Kenna G, Klaric M, Lester C, Mahony C, Ouedraogo G, Paini A, Schepky A; Cosmetics Europe.

Frontiers in Toxicology 2021

Internal Threshold of Toxicological Concern (iTTC): Where We Are Today and What Is Possible in the Near Future

Ellison CA, Api AM, Becker RA, Efremenko AY, Gadhia S, Hack CE, Hewitt NJ, Varcin M, Schepky A.

npj Aging and Mechanisms of Disease 2021

Modeling transcriptomic age using knowledge-primed artificial neural networks

Holzscheck N, Falckenhayn C, Söhle J, Kristof B, Siegner R, Werner A, Schössow J, Jürgens C, Völzke H, Wenck H, Winnefeld M, Grönniger E, Kaderali L.

Skin Research and Technology 2021

Mobile snapshot hyperspectral imaging device for skin evaluation using diffractive optical elements

Kern C, Speck U, Riesenberg R, Reble C, Khazaka G, Zieger M, Kaatz M, De Gregorio M, Fischer F.

Journal of Biophotonics 2021

Noninvasive measurement of the 308 nm LED-based UVB protection factor of sunscreens

Kobylinski S, Reble C, Schanzer S, Gersonde I, Wiora G, Lobo Ploch N, Karrer H, Kolbe L, Khazaka G, Lademann J, Meinke MC.

Toxicology 2021

Characterization of application scenario-dependent pharmacokinetics and pharmacodynamic properties of permethrin and hyperforin in a dynamic skin and liver multi-organ-chip model

Kühnl J, Tao TP, Brandmair K, Gerlach S, Rings T, Müller-Vieira U, Przibilla J, Genies C, Jaques-Jamin C, Schepky A, Marx U, Hewitt NJ, Maschmeyer I.

Toxicology in Vitro 2021

Metabolism and plasma protein binding of 16 straight- and branched-chain parabens in in vitro liver and skin models

Lester C, Hewitt NJ, Müller-Vieira U, Mayer M, Ellison C, Duplan H, Genies C, Jacques-Jamin C, Fabian E, Sorrell I, Lange D, Schepky A, Grégoire S.

Free Radical Biology and Medicine 2021

Anti-ageing effects of ubiquinone and ubiquinol in a senescence model of human dermal fibroblasts

Marcheggiani F, Kordes S, Cirilli I, Orlando P, Silvestri S, Vogelsang A, Möller N, Blatt T, Weise JM, Damiani E, Tiano L.

Cells 2021

Evaluation of Immunomodulatory Responses and Changed Wound Healing in Type 2 Diabetes-A Study Exploiting Dermal Fibroblasts from Diabetic and Non-Diabetic Human Donors

Nickel K, Wensorra U, Wenck H, Peters N, Genth H.

International Journal of Cosmetic Science 2021

Effective reduction of post-inflammatory hyperpigmentation with the tyrosinase inhibitor isobutylamido-thiazolyl-resorcinol (Thiamidol)

Roggenkamp D, Dlova N, Mann T, Batzer J, Riedel J, Kausch M, Zoric I, Kolbe L.

The Journal of Dermatology 2021

Thiamidol(®) in moderate-to-severe melasma: 24-week, randomized, double-blind, vehicle-controlled clinical study with subsequent regression phase

Roggenkamp D, Sammain A, Fürstenau M, Kausch M, Passeron T, Kolbe L.

Photodermatology, Photoimmunology and Photomedicine 2021

Multi-laboratory study of hybrid diffuse reflectance spectroscopy to assess sunscreen SPF and UVA-PFs

Ruvolo E, Rohr M, Oliveira S, Nogueira L, Carvalho J, Cole C.

Journal of Applied Toxicology 2021

Demonstration of the first-pass metabolism in the skin of the hair dye, 4-amino-2-hydroxytoluene, using the Chip2 skin-liver microphysiological model

Tao TP, Brandmair K, Gerlach S, Przibilla J, Géniès C, Jacques-Jamin C, Schepky A, Marx U, Hewitt NJ, Maschmeyer I, Kühnl J.

Journal of Biophotonics 2021

In vivo sun protection factor and UVA protection factor determination using (hybrid) diffuse reflectance spectroscopy and a multi-lambda-LED light source

Throm CM, Wiora G, Reble C, Schleusener J, Schanzer S, Karrer H, Kolbe L, Khazaka G, Meinke MC, Lademann J.

Der Hautarzt 2021

[Influence of an adjuvant treatment with an emollient containing 10 % urea, ceramides, glycerin und glyceryl glucoside in patients with psoriasis vulgaris]

von Martial S, Nippel G, Schmidt L, Sammain A, Schölermann A, Presto S, Tsianakas A.

Pharmaceuticals 2021

Predicting the Skin Sensitization Potential of Small Molecules with Machine Learning Models Trained on Biologically Meaningful Descriptors

Wilm A, Garcia de Lomana M, Stork C, Mathai N, Hirte S, Norinder U, Kühnl J, Kirchmair J.

Chemical Research in Toxicology 2021

Skin Doctor CP: Conformal Prediction of the Skin Sensitization Potential of Small Organic Molecules

Wilm A, Norinder U, Agea MI, de Bruyn Kops C, Stork C, Kühnl J, Kirchmair J.

Scientific Reports 2021

A method to analyze the influence of mechanical strain on dermal collagen morphologies

Witte M, Rübhausen M, Jaspers S, Wenck H, Fischer F.

Skin Research and Technology 2021

Multi-wavelength, handheld laser speckle imaging for skin evaluation

Zieger M, Kaatz M, Springer S, Riesenberg R, Wuttig A, Kanka M, Stanca S, Reble C, Khazaka G, Sieg R, De Gregorio M, Sattler M, Fischer F.

2020

Microorganisms 2020

Staphylococcus saccharolyticus: An Overlooked Human Skin Colonizer

Ahle CM, Stødkilde K, Afshar M, Poehlein A, Ogilvie LA, Söderquist B, Hüpeden J, Brüggemann H.

Journal of Applied Toxicology 2020

Use of human liver and EpiSkin™ S9 subcellular fractions as a screening assays to compare the in vitro hepatic and dermal metabolism of 47 cosmetics-relevant chemicals

Eilstein J, Grégoire S, Fabre A, Arbey E, Géniès C, Duplan H, Rothe H, Ellison C, Cubberley R, Schepky A, Lange D, Klaric M, Hewitt NJ, Jacques-Jamin C.

Toxicology in Vitro 2020

Partition coefficient and diffusion coefficient determinations of 50 compounds in human intact skin, isolated skin layers and isolated stratum corneum lipids

Ellison CA, Tankersley KO, Obringer CM, Carr GJ, Manwaring J, Rothe H, Duplan H, Géniès C, Grégoire S, Hewitt NJ, Jamin CJ, Klaric M, Lange D, Rolaki A, Schepky A.

Journal of Applied Toxicology 2020

Comparison of the metabolism of 10 cosmetics-relevant chemicals in EpiSkin™ S9 subcellular fractions and in vitro human skin explants

Géniès C, Jacques-Jamin C, Duplan H, Rothe H, Ellison C, Cubberley R, Schepky A, Lange D, Klaric M, Hewitt NJ, Grégoire S, Arbey E, Fabre A, Eilstein J.

Regulatory Toxicology and Pharmacology 2020

Development of a next generation risk assessment framework for the evaluation of skin sensitisation of cosmetic ingredients

Gilmour N, Kern PS, Alépée N, Boislève F, Bury D, Clouet E, Hirota M, Hoffmann S, Kühnl J, Lalko JF, Mewes K, Miyazawa M, Nishida H, Osmani A, Petersohn D, Sekine S, van Vliet E, Klaric M.

American Journal of Clinical Dermatology 2020

Efficacy of Nonprescription Moisturizers for Atopic Dermatitis: An Updated Review of Clinical Evidence

Hebert AA, Rippke F, Weber TM, Nicol NH.

Journal of Applied Toxicology 2020

Measurement of the penetration of 56 cosmetic relevant chemicals into and through human skin using a standardized protocol

Hewitt NJ, Grégoire S, Cubberley R, Duplan H, Eilstein J, Ellison C, Lester C, Fabian E, Fernandez J, Géniès C, Jacques-Jamin C, Klaric M, Rothe H, Sorrell I, Lange D, Schepky A.

Tissue Engineering Part A 2020

Human Adipose-Derived Mesenchymal Stromal/Stem Cell Spheroids Possess High Adipogenic Capacity and Acquire an Adipose Tissue-like Extracellular Matrix Pattern

Hoefner C, Muhr C, Horder H, Wiesner M, Wittmann K, Lukaszyk D, Radeloff K, Winnefeld M, Becker M, Blunk T, Bauer-Kreisel P.

Aging 2020

Multi-omics network analysis reveals distinct stages in the human aging progression in epidermal tissue

Holzscheck N, Söhle J, Kristof B, Grönniger E, Gallinat S, Wenck H, Winnefeld M, Falckenhayn C, Kaderali L.

Scientific Reports 2020

Concomitant DNA methylation and transcriptome signatures define epidermal responses to acute solar UV radiation

Holzscheck N, Söhle J, Schläger T, Falckenhayn C, Grönniger E, Kolbe L, Wenck H, Terstegen L, Kaderali L, Winnefeld M, Gorges K.

Regulatory Toxicology and Pharmacology 2020

Response to "OECD 428 in vitro dermal absorption mass balance performance based on our in-house database of pesticide studies"

Kluxen FM, Grégoire S, Schepky A, Hewitt NJ, Klaric M, Domoradzki JY, Felkers E, Fisher P, McEuen SF, Parr-Dobrzanski R, Fabian E, Wiemann C.

Photodermatology, Photoimmunology & Photomedicine 2020

High-energy visible light at ambient doses and intensities induces oxidative stress of skin-Protective effects of the antioxidant and Nrf2 inducer Licochalcone A in vitro and in vivo

Mann T, Eggers K, Rippke F, Tesch M, Buerger A, Darvin ME, Schanzer S, Meinke MC, Lademann J, Kolbe L.

ALTEX 2020

Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development

Marx U, Akabane T, Andersson TB, Baker E, Beilmann M, Beken S, Brendler-Schwaab S, Cirit M, David R, Dehne EM, Durieux I, Ewart L, Fitzpatrick SC, Frey O, Fuchs F, Griffith LG, Hamilton GA, Hartung T, Hoeng J, Hogberg H, Hughes DJ, Ingber DE, Iskandar A, Kanamori T, Kojima H, Kuehnl J, Leist M, Li B, Loskill P, Mendrick DL, Neumann T, Pallocca G, Rusyn I, Smirnova L, Steger-Hartmann T, Tagle DA, Tonevitsky A, Tsyb S, Trapecar M, Van de Water B, Van den Eijnden-van Raaij J, Vulto P, Watanabe K, Wolf A, Zhou X, Roth A.

International Journal of Cosmetic Science 2020

Thiamidol containing treatment regimens in facial hyperpigmentation: An international multi-centre approach consisting of a double-blind, controlled, split-face study and of an open-label, real-world study

Philipp-Dormston WG, Vila Echagüe A, Pérez Damonte SH, Riedel J, Filbry A, Warnke K, Lofrano C, Roggenkamp D, Nippel G.

International Journal of Cosmetic Science 2020

Validation of a new in vitro Sun Protection Factor method to include a wide range of sunscreen product emulsion types

Pissavini M, Tricaud C, Wiener G, Lauer A, Contier M, Kolbe L, Trullás Cabanas C, Boyer F, Meredith E, de Lapuente J, Dietrich E, Matts PJ.

Photodermatology, Photoimmunology and Photomedicine 2020

Evaluation of sunscreen efficacy over time and re-application using hybrid diffuse reflectance spectroscopy

Ruvolo E, Aeschliman L, Cole C.

Journal of Cosmetic Dermatology 2020

Efficacy of a skin care cream with TRPV1 inhibitor 4-t-butylcyclohexanol in the topical therapy of perioral dermatitis

Srour J, Bengel J, Linden T, Jovanovic Z, Roggenkamp D, Reinholz M, Rothenberger C, Neufang G, Wollenberg A.

PLOS One 2020

Noise reduction and quantification of fiber orientations in greyscale images

Witte M, Jaspers S, Wenck H, Rübhausen M, Fischer F.

Scientific Reports 2020

General method for classification of fiber families in fiber-reinforced materials: application to in-vivo human skin images

Witte M, Jaspers S, Wenck H, Rübhausen M, Fischer F.

2019

Toxicology in Vitro 2019

Development of a defined approach for eye irritation or serious eye damage for neat liquids based on cosmetics Europe analysis of in vitro RhCE and BCOP test methods

Alépée N, Adriaens E, Abo T, Bagley D, Desprez B, Hibatallah J, Mewes K, Pfannenbecker U, Sala À, Van Rompay AR, Verstraelen S, McNamee P.

Toxicology in Vitro 2019

Development of a defined approach for eye irritation or serious eye damage for liquids, neat and in dilution, based on cosmetics Europe analysis of in vitro STE and BCOP test methods

Alépée N, Adriaens E, Abo T, Bagley D, Desprez B, Hibatallah J, Mewes K, Pfannenbecker U, Sala À, Van Rompay AR, Verstraelen S, McNamee P.

Journal of Investigative Dermatology 2019

Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild to Moderate Melasma

Arrowitz C, Schoelermann AM, Mann T, Jiang LI, Weber T, Kolbe L.

Regulatory Toxicology and Pharmacology 2019

Challenges in working towards an internal threshold of toxicological concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop

Ellison CA, Blackburn KL, Carmichael PL, Clewell HJ 3rd, Cronin MTD, Desprez B, Escher SE, Ferguson SS, Grégoire S, Hewitt NJ, Hollnagel HM, Klaric M, Patel A, Salhi S, Schepky A, Schmitt BG, Wambaugh JF, Worth A.

Journal of Applied Toxicology 2019

Comparison of the metabolism of 10 chemicals in human and pig skin explants

Géniès C, Jamin EL, Debrauwer L, Zalko D, Person EN, Eilstein J, Grégoire S, Schepky A, Lange D, Ellison C, Roe A, Salhi S, Cubberley R, Hewitt NJ, Rothe H, Klaric M, Duplan H, Jacques-Jamin C.

Skin Pharmacology and Physiology 2019

Use of a Simple in vitro Test to Assess Loss of Chemical due to Volatility during an in vitro Human Skin Absorption Study

Grégoire S, Cubberley R, Duplan H, Eilstein J, Hewitt NJ, Jacques-Jamin C, Genies C, Klaric M, Rothe H, Ellison C, Fernandez J, Schepky A.

Pigment Cell & Melanoma Research 2019

Visible light accelerates the ultraviolet A-induced degradation of eumelanin and pheomelanin

Ito S, Kolbe L, Weets G, Wakamatsu K.

Regulatory Toxicology and Pharmacology 2019

Dermal absorption study OECD TG 428 mass balance recommendations based on the EFSA database

Kluxen FM, Grégoire S, Schepky A, Hewitt NJ, Klaric M, Domoradzki JY, Felkers E, Fernandes J, Fisher P, McEuen SF, Parr-Dobrzanski R, Wiemann C.

International Journal of Cosmetic Science 2019

Anti-inflammatory / anti-oxidant activity of ingredients of sunscreen products? Implications for SPF

Kolbe L, Pissavini M, Tricaud C, Trullás Cabanas C, Dietrich E, Matts PJ.

Aging 2019

Modulation of Coenzyme Q(10) content and oxidative status in human dermal fibroblasts using HMG-CoA reductase inhibitor over a broad range of concentrations. From mitohormesis to mitochondrial dysfunction and accelerated aging

Marcheggiani F, Cirilli I, Orlando P, Silvestri S, Vogelsang A, Knott A, Blatt T, Weise JM, Tiano L.

Journal of Computational Biology 2019

Mitochondrial Morphologies Driven by Energy-Consuming Cell Sites in a Spatially and Time-Resolved Quality Model

Mellem D, Fischer F, Jaspers S, Wenck H, Rübhausen M.

Journal of the European Academy of Dermatology and Venereology 2019

Real-life study of anti-itching effects of a cream containing menthoxypropanediol, a TRPM8 agonist, in atopic dermatitis patients

Misery L, Santerre A, Batardière A, Hornez N, Nedelec AS, Le Caër F, Bourgeois P, Huet F, Neufang G.

Differentiation 2019

Comparing the use of differentiated adipose-derived stem cells and mature adipocytes to model adipose tissue in vitro

Volz AC, Omengo B, Gehrke S, Kluger PJ.

International Journal of Molecular Sciences 2019

Skin Doctor: Machine Learning Models for Skin Sensitization Prediction that Provide Estimates and Indicators of Prediction Reliability

Wilm A, Stork C, Bauer C, Schepky A, Kühnl J, Kirchmair J.

2018

Journal of Photochemistry and Photobiology B: Biology 2018

Multicenter methodology comparison of the FDA and ISO standard for measurement of in vitro UVA protection of sunscreen products

Bielfeldt S, Klette E, Rohr M, Herzog B, Grumelard J, Hanay C, Heinrich U, Hansen P, Kockott D, Lademann J, Mendrok-Edinger C, Peters S, Rudolph T, Schläger T, Tronnier H, Wiechers S, Zastrow L, Pflücker F.

Aging 2018

PhotoAgeClock: deep learning algorithms for development of non-invasive visual biomarkers of aging

Bobrov E, Georgievskaya A, Kiselev K, Sevastopolsky A, Zhavoronkov A, Gurov S, Rudakov K, Del Pilar Bonilla Tobar M, Jaspers S, Clemann S.

Toxicology in Vitro 2018

A strategy for systemic toxicity assessment based on non-animal approaches: The Cosmetics Europe Long Range Science Strategy programme

Desprez B, Dent M, Keller D, Klaric M, Ouédraogo G, Cubberley R, Duplan H, Eilstein J, Ellison C, Grégoire S, Hewitt NJ, Jacques-Jamin C, Lange D, Roe A, Rothe H, Blaauboer BJ, Schepky A, Mahony C.

Critical Reviews in Toxicology 2018

Non-animal methods to predict skin sensitization (I): the Cosmetics Europe database<sup/>

Hoffmann S, Kleinstreuer N, Alépée N, Allen D, Api AM, Ashikaga T, Clouet E, Cluzel M, Desprez B, Gellatly N, Goebel C, Kern PS, Klaric M, Kühnl J, Lalko JF, Martinozzi-Teissier S, Mewes K, Miyazawa M, Parakhia R, van Vliet E, Zang Q, Petersohn D.

Critical Reviews in Toxicology 2018

Non-animal methods to predict skin sensitization (II): an assessment of defined approaches (*)

Kleinstreuer NC, Hoffmann S, Alépée N, Allen D, Ashikaga T, Casey W, Clouet E, Cluzel M, Desprez B, Gellatly N, Göbel C, Kern PS, Klaric M, Kühnl J, Martinozzi-Teissier S, Mewes K, Miyazawa M, Strickland J, van Vliet E, Zang Q, Petersohn D.

Genome Research 2018

Integrated analysis of motif activity and gene expression changes of transcription factors

Madsen JGS, Rauch A, Van Hauwaert EL, Schmidt SF, Winnefeld M, Mandrup S.

Journal of Investigative Dermatology 2018

Inhibition of Human Tyrosinase Requires Molecular Motifs Distinctively Different from Mushroom Tyrosinase

Mann T, Gerwat W, Batzer J, Eggers K, Scherner C, Wenck H, Stäb F, Hearing VJ, Röhm KH, Kolbe L.

International Journal of Molecular Sciences 2018

Structure-Activity Relationships of Thiazolyl Resorcinols, Potent and Selective Inhibitors of Human Tyrosinase

Mann T, Scherner C, Röhm KH, Kolbe L.

International Journal of Cosmetic Science 2018

Validation of an in vitro sun protection factor (SPF) method in blinded ring-testing

Pissavini M, Tricaud C, Wiener G, Lauer A, Contier M, Kolbe L, Trullás Cabanas C, Boyer F, Nollent V, Meredith E, Dietrich E, Matts PJ.

Nature Communications 2018

Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin

Rodríguez-Paredes M, Bormann F, Raddatz G, Gutekunst J, Lucena-Porcel C, Köhler F, Wurzer E, Schmidt K, Gallinat S, Wenck H, Röwert-Huber J, Denisova E, Feuerbach L, Park J, Brors B, Herpel E, Nindl I, Hofmann TG, Winnefeld M, Lyko F.

Archives of Toxicology 2018

A methodology for the assessment of inhalation exposure to aluminium from antiperspirant sprays

Schwarz K, Pappa G, Miertsch H, Scheel J, Koch W.

Toxicology Letters 2018

Principles for the safety evaluation of cosmetic powders

Steiling W, Almeida JF, Assaf Vandecasteele H, Gilpin S, Kawamoto T, O'Keeffe L, Pappa G, Rettinger K, Rothe H, Bowden AM.

ALTEX 2018

State-of-the-art and new options to assess T cell activation by skin sensitizers: Cosmetics Europe Workshop

van Vliet E, Kühnl J, Goebel C, Martinozzi-Teissier S, Alépée N, Ashikaga T, Blömeke B, Del Bufalo A, Cluzel M, Corsini E, Delrue N, Desprez B, Gellatly N, Giese C, Gribaldo L, Hoffmann S, Klaric M, Maillere B, Naisbitt D, Pallardy M, Vocanson M, Petersohn D.

Critical Reviews in Toxicology 2018

Computational approaches for skin sensitization prediction

Wilm A, Kühnl J, Kirchmair J.

2017

Archives of Toxicology 2017

Cosmetics Europe compilation of historical serious eye damage/eye irritation in vivo data analysed by drivers of classification to support the selection of chemicals for development and evaluation of alternative methods/strategies: the Draize eye test Reference Database (DRD)

Barroso J, Pfannenbecker U, Adriaens E, Alépée N, Cluzel M, De Smedt A, Hibatallah J, Klaric M, Mewes KR, Millet M, Templier M, McNamee P.

Experimental Dermatology 2017

Molecular and histological characterization of age spots

Choi W, Yin L, Smuda C, Batzer J, Hearing VJ, Kolbe L.

Experimental Dermatology 2017

Identification of miR-126 as a new regulator of skin ageing

Fiedler J, Grönniger E, Pfanne A, Brönneke S, Schmidt K, Falk CS, Wenck H, Terstegen L, Thum T, Winnefeld M.

International Journal of Cosmetic Science 2017

Conventional sunscreen application does not lead to sufficient body coverage

Jovanovic Z, Schornstein T, Sutor A, Neufang G, Hagens R.

Journal of Tissue Engineering 2017

Methacrylated gelatin/hyaluronan-based hydrogels for soft tissue engineering

Kessler L, Gehrke S, Winnefeld M, Huber B, Hoch E, Walter T, Wyrwa R, Schnabelrauch M, Schmidt M, Kückelhaus M, Lehnhardt M, Hirsch T, Jacobsen F.

BMC Genomics 2017

An integrative metabolomics and transcriptomics study to identify metabolic alterations in aged skin of humans in vivo

Kuehne A, Hildebrand J, Soehle J, Wenck H, Terstegen L, Gallinat S, Knott A, Winnefeld M, Zamboni N.

PLOS One 2017

Fragmentation of the mitochondrial network in skin in vivo

Mellem D, Sattler M, Pagel-Wolff S, Jaspers S, Wenck H, Rübhausen MA, Fischer F.

PLOS One 2017

Hair and stress: A pilot study of hair and cytokine balance alteration in healthy young women under major exam stress

Peters EMJ, Müller Y, Snaga W, Fliege H, Reißhauer A, Schmidt-Rose T, Max H, Schweiger D, Rose M, Kruse J.

Toxicology Letters 2017

Review of data on the dermal penetration of mineral oils and waxes used in cosmetic applications

Petry T, Bury D, Fautz R, Hauser M, Huber B, Markowetz A, Mishra S, Rettinger K, Schuh W, Teichert T.

Experimental Dermatology 2017

Impaired glyoxalase activity is associated with reduced expression of neurotrophic factors and pro-inflammatory processes in diabetic skin cells

Reichert O, Fleming T, Neufang G, Schmelz M, Genth H, Kaever V, Wenck H, Stäb F, Terstegen L, Kolbe L, Roggenkamp D.

International Journal of Cosmetic Science 2017

Comparison of protocols measuring diffusion and partition coefficients in the stratum corneum

Rothe H, Obringer C, Manwaring J, Avci C, Wargniez W, Eilstein J, Hewitt N, Cubberley R, Duplan H, Lange D, Jacques-Jamin C, Klaric M, Schepky A, Grégoire S.

Journal of the European Academy of Dermatology and Venereology 2017

Novel TRPM8 agonist cooling compound against chronic itch: results from a randomized, double-blind, controlled, pilot study in dry skin

Ständer S, Augustin M, Roggenkamp D, Blome C, Heitkemper T, Worthmann AC, Neufang G.

International Journal of Cosmetic Science 2017

Effective axillary malodour reduction by polyquaternium-16-containing deodorants

Traupe B, Fölster H, Max H, Schulz J.

International Journal of Cosmetic Science 2017

Not only age but also tactile perception influences the preference for cosmetic creams applied to the forearm

Trautmann M, Wendel V, Prinz D, Primmel B, Willging G, Nagorsen E, Suckert A, Gehm S, Brandt M, Ballay P, Godde B.

2016

Toxicology in Vitro 2016

Assessment of cosmetic ingredients in the in vitro reconstructed human epidermis test method EpiSkin™ using HPLC/UPLC-spectrophotometry in the MTT-reduction assay

Alépée N, Hibatallah J, Klaric M, Mewes KR, Pfannenbecker U, McNamee P.

International Journal of Cosmetic Science 2016

The 'Dispersal Rate' - a product dependent characteristic to predict the reliability of the calibrated in vitro SPF on WW5 plates

Batzer J, Bleckmann A, Lerg H, Schwanke F, Schläger T.

Aging Cell 2016

Reduced DNA methylation patterning and transcriptional connectivity define human skin aging

Bormann F, Rodríguez-Paredes M, Hagemann S, Manchanda H, Kristof B, Gutekunst J, Raddatz G, Haas R, Terstegen L, Wenck H, Kaderali L, Winnefeld M, Lyko F.

Toxicology in Vitro 2016

Comparison of protocols for measuring cosmetic ingredient distribution in human and pig skin

Gerstel D, Jacques-Jamin C, Schepky A, Cubberley R, Eilstein J, Grégoire S, Hewitt N, Klaric M, Rothe H, Duplan H.

Scientific Reports 2016

Visualizing tropoelastin in a long-term human elastic fibre cell culture model

Halm M, Schenke-Layland K, Jaspers S, Wenck H, Fischer F.

Tissue Engineering Part C Methods 2016

Integration of Mature Adipocytes to Build-Up a Functional Three-Layered Full-Skin Equivalent

Huber B, Link A, Linke K, Gehrke SA, Winnefeld M, Kluger PJ.

Journal of Proteomics 2016

Homogenization of tissues via picosecond-infrared laser (PIRL) ablation: Giving a closer view on the in-vivo composition of protein species as compared to mechanical homogenization

Kwiatkowski M, Wurlitzer M, Krutilin A, Kiani P, Nimer R, Omidi M, Mannaa A, Bussmann T, Bartkowiak K, Kruber S, Uschold S, Steffen P, Lübberstedt J, Küpker N, Petersen H, Knecht R, Hansen NO, Zarrine-Afsar A, Robertson WD, Miller RJD, Schlüter H.

ALTEX 2016

Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

Marx U, Andersson TB, Bahinski A, Beilmann M, Beken S, Cassee FR, Cirit M, Daneshian M, Fitzpatrick S, Frey O, Gaertner C, Giese C, Griffith L, Hartung T, Heringa MB, Hoeng J, de Jong WH, Kojima H, Kuehnl J, Leist M, Luch A, Maschmeyer I, Sakharov D, Sips AJ, Steger-Hartmann T, Tagle DA, Tonevitsky A, Tralau T, Tsyb S, van de Stolpe A, Vandebriel R, Vulto P, Wang J, Wiest J, Rodenburg M, Roth A.

PLOS One 2016

Quality Saving Mechanisms of Mitochondria during Aging in a Fully Time-Dependent Computational Biophysical Model

Mellem D, Fischer F, Jaspers S, Wenck H, Rübhausen M.

Experimental Dermatology 2016

Menthoxypropanediol inhibits nerve growth factor-induced nerve fibre sprouting in coculture models of sensory neurons and skin cells

Roggenkamp D, Worthmann AC, Sulzberger M, Wenck H, Stäb F, Neufang G.

Journal of the European Academy of Dermatology and Venereology 2016

Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin

Schoelermann AM, Jung KA, Buck B, Grönniger E, Conzelmann S.

Journal of the European Academy of Dermatology and Venereology 2016

Skin compatibility and efficacy of a cosmetic skin care regimen with licochalcone A and 4-t-butylcyclohexanol in patients with rosacea subtype I

Schoelermann AM, Weber TM, Arrowitz C, Rizer RL, Qian K, Babcock M.

International Journal of Cosmetic Science 2016

Towards a body hair atlas of women of caucasian ethnicity

Schweiger D, Hoff A, Scheede S, Fischer F, Tilsner J, Lüttke J, Neumann Y, Hagens R.

Journal of Dermatological Science 2016

Inhibition of Propionibacterium acnes associated biofilm formation by Decanediol

Sulzberger M, Fölster H, Sattler M, Rippke F, Grönniger E.

Journal of the European Academy of Dermatology and Venereology 2016

Effective treatment for sensitive skin: 4-t-butylcyclohexanol and licochalcone A

Sulzberger M, Worthmann AC, Holtzmann U, Buck B, Jung KA, Schoelermann AM, Rippke F, Stäb F, Wenck H, Neufang G, Grönniger E.

2015

Toxicology in Vitro 2015

Use of HPLC/UPLC-spectrophotometry for detection of formazan in in vitro Reconstructed human Tissue (RhT)-based test methods employing the MTT-reduction assay to expand their applicability to strongly coloured test chemicals

Alépée N, Barroso J, De Smedt A, De Wever B, Hibatallah J, Klaric M, Mewes KR, Millet M, Pfannenbecker U, Tailhardat M, Templier M, McNamee P.

Angiogenesis 2015

Genome-wide expression analysis of wounded skin reveals novel genes involved in angiogenesis

Brönneke S, Brückner B, Söhle J, Siegner R, Smuda C, Stäb F, Wenck H, Kolbe L, Grönniger E, Winnefeld M.

Clinical, Cosmetic and Investigational Dermatology 2015

Birch pollen influence the severity of atopic eczema - prospective clinical cohort pilot study and ex vivo penetration study

Fölster-Holst R, Galecka J, Weißmantel S, Dickschat U, Rippke F, Bohnsack K, Werfel T, Wichmann K, Buchner M, Schwarz T, Vogt A, Lademann J, Meinke MC.

Cell 2015

GABA blocks pathological but not acute TRPV1 pain signals

Hanack C, Moroni M, Lima WC, Wende H, Kirchner M, Adelfinger L, Schrenk-Siemens K, Tappe-Theodor A, Wetzel C, Kuich PH, Gassmann M, Roggenkamp D, Bettler B, Lewin GR, Selbach M, Siemens J.

Biofactors 2015

Topical treatment with coenzyme Q10-containing formulas improves skin's Q10 level and provides antioxidative effects

Knott A, Achterberg V, Smuda C, Mielke H, Sperling G, Dunckelmann K, Vogelsang A, Krüger A, Schwengler H, Behtash M, Kristof S, Diekmann H, Eisenberg T, Berroth A, Hildebrand J, Siegner R, Winnefeld M, Teuber F, Fey S, Möbius J, Retzer D, Burkhardt T, Lüttke J, Blatt T.

Molecular Cell 2015

Acute Activation of Oxidative Pentose Phosphate Pathway as First-Line Response to Oxidative Stress in Human Skin Cells

Kuehne A, Emmert H, Soehle J, Winnefeld M, Fischer F, Wenck H, Gallinat S, Terstegen L, Lucius R, Hildebrand J, Zamboni N.

Experimental Dermatology 2015

Licochalcone A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo

Kühnl J, Roggenkamp D, Gehrke SA, Stäb F, Wenck H, Kolbe L, Neufang G.

Drug Delivery 2015

Confocal Raman investigation of diffusion processes in monolithic type transdermal drug delivery systems

Meyer S, Heinsohn G, Wolber R, Pörtner R, Nierle J.

Journal of Investigative Dermatology 2015

Endothelial Cells Promote Pigmentation through Endothelin Receptor B Activation

Regazzetti C, De Donatis GM, Ghorbel HH, Cardot-Leccia N, Ambrosetti D, Bahadoran P, Chignon-Sicard B, Lacour JP, Ballotti R, Mahns A, Passeron T.

Experimental Dermatology 2015

UV radiation induces CXCL5 expression in human skin

Reichert O, Kolbe L, Terstegen L, Staeb F, Wenck H, Schmelz M, Genth H, Kaever V, Roggenkamp D, Neufang G.

Toxicology in Vitro 2015

Evaluation of an optimized protocol using human peripheral blood monocyte derived dendritic cells for the in vitro detection of sensitizers: Results of a ring study in five laboratories

Reuter H, Gerlach S, Spieker J, Ryan C, Bauch C, Mangez C, Winkler P, Landsiedel R, Templier M, Mignot A, Gerberick F, Wenck H, Aeby P, Schepky A.

Journal of Investigative Dermatology 2015

Highly efficient and compatible shampoo for use after hair transplant

Schweiger D, Schoelermann AM, Filbry A, Hamann T, Moser C, Rippke F.

BioMed Research International 2015

Is vitamin D deficiency related to accumulation of advanced glycation end products, markers of inflammation, and oxidative stress in diabetic subjects?

Šebeková K, Stürmer M, Fazeli G, Bahner U, Stäb F, Heidland A.

Journal of Renal Nutrition 2015

25-hydroxyvitamin d and advanced glycation endproducts in healthy and hypertensive subjects: are there interactions?

Stürmer M, Šebeková K, Fazeli G, Bahner U, Stäb F, Heidland A.

Journal of the Dermatology Nurses’ Association 2015

Efficacy and Tolerability of Steroid-Free, Over-the-Counter Treatment Formulations in Infants and Children With Atopic Dermatitis

Weber TM, Herndon JH Jr, Ewer M, Stephens TJ, Flick I, Filbry A, Neufang G, Schoelermann AM.

Journal of Investigative Dermatology 2015

Identification of Genes Expressed in Hyperpigmented Skin Using Meta-Analysis of Microarray Data Sets

Yin L, Coelho SG, Valencia JC, Ebsen D, Mahns A, Smuda C, Miller SA, Beer JZ, Kolbe L, Hearing VJ.

2014

Journal of Investigative Dermatology 2014

The nano-scale mechanical properties of the extracellular matrix regulate dermal fibroblast function

Achterberg VF, Buscemi L, Diekmann H, Smith-Clerc J, Schwengler H, Meister JJ, Wenck H, Gallinat S, Hinz B.

Dermatitis 2014

Categorization of chemicals according to their relative human skin sensitizing potency

Basketter DA, Alépée N, Ashikaga T, Barroso J, Gilmour N, Goebel C, Hibatallah J, Hoffmann S, Kern P, Martinozzi-Teissier S, Maxwell G, Reisinger K, Sakaguchi H, Schepky A, Tailhardat M, Templier M.

Experimental Dermatology 2014

Glutathione-conjugated sulfanylalkanols are substrates for ABCC11 and γ-glutamyl transferase 1: a potential new pathway for the formation of odorant precursors in the apocrine sweat gland

Baumann T, Bergmann S, Schmidt-Rose T, Max H, Martin A, Enthaler B, Terstegen L, Schweiger D, Kalbacher H, Wenck H, Jedlitschky G, Jovanovic Z.

Regulatory Toxicology and Pharmacology 2014

PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA--EURL ECVAM ADME workshop

Bessems JG, Loizou G, Krishnan K, Clewell HJ 3rd, Bernasconi C, Bois F, Coecke S, Collnot EM, Diembeck W, Farcal LR, Geraets L, Gundert-Remy U, Kramer N, Küsters G, Leite SB, Pelkonen OR, Schröder K, Testai E, Wilk-Zasadna I, Zaldívar-Comenges JM.

Journal of Dermatological Science 2014

The matricellular protein periostin contributes to proper collagen function and is downregulated during skin aging

Egbert M, Ruetze M, Sattler M, Wenck H, Gallinat S, Lucius R, Weise JM.

PLOS One 2014

Electrospun poly(ester-Urethane)- and poly(ester-Urethane-Urea) fleeces as promising tissue engineering scaffolds for adipose-derived stem cells

Gugerell A, Kober J, Laube T, Walter T, Nürnberger S, Grönniger E, Brönneke S, Wyrwa R, Schnabelrauch M, Keck M.

European Journal of Pharmaceutics and Biopharmaceutics 2014

Plasticization and antiplasticization of an acrylic pressure sensitive adhesive by ibuprofen and their effect on the adhesion properties

Michaelis M, Brummer R, Leopold CS.

Genomics Data 2014

Gene expression in response to cyclic mechanical stretch in primary human dermal fibroblasts

Reichenbach M, Reimann K, Reuter H.

Journal of Biological Chemistry 2014

Chemosensory information processing between keratinocytes and trigeminal neurons

Sondersorg AC, Busse D, Kyereme J, Rothermel M, Neufang G, Gisselmann G, Hatt H, Conrad H.

2013

Journal of Allergy and Clinical Immunology 2013

Role of fibroblasts in the pathogenesis of atopic dermatitis

Berroth A, Kühnl J, Kurschat N, Schwarz A, Stäb F, Schwarz T, Wenck H, Fölster-Holst R, Neufang G.

Experimental Dermatology 2013

Oxytocin modulates proliferation and stress responses of human skin cells: implications for atopic dermatitis

Deing V, Roggenkamp D, Kühnl J, Gruschka A, Stäb F, Wenck H, Bürkle A, Neufang G.

Rapid Communications in Mass Spectrometry 2013

Influence of various on-tissue washing procedures on the entire protein quantity and the quality of matrix-assisted laser desorption/ionization spectra

Enthaler B, Bussmann T, Pruns JK, Rapp C, Fischer M, Vietzke JP.

Analytical and Bioanalytical Chemistry 2013

MALDI imaging in human skin tissue sections: focus on various matrices and enzymes

Enthaler B, Trusch M, Fischer M, Rapp C, Pruns JK, Vietzke JP.

PLOS One 2013

Epigenetic regulation of depot-specific gene expression in adipose tissue

Gehrke S, Brueckner B, Schepky A, Klein J, Iwen A, Bosch TC, Wenck H, Winnefeld M, Hagemann S.

Molecular Dermatology 2013

MicroRNA profiling during human keratinocyte differentiation using a quantitative real-time PCR method

Hildebrand J, Grundhoff A, Gallinat S, Wenck H, Knott A.

Journal of the European Academy of Dermatology and Venereology 2013

4-n-butylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation

Kolbe L, Mann T, Gerwat W, Batzer J, Ahlheit S, Scherner C, Wenck H, Stäb F.

Talanta 2013

A novel sampling method for identification of endogenous skin surface compounds by use of DART-MS and MALDI-MS

Mess A, Enthaler B, Fischer M, Rapp C, Pruns JK, Vietzke JP.

Toxicology in Vitro 2013

Cosmetics Europe multi-laboratory pre-validation of the EpiOcular™ reconstituted human tissue test method for the prediction of eye irritation

Pfannenbecker U, Bessou-Touya S, Faller C, Harbell J, Jacob T, Raabe H, Tailhardat M, Alépée N, De Smedt A, De Wever B, Jones P, Kaluzhny Y, Le Varlet B, McNamee P, Marrec-Fairley M, Van Goethem F.

Journal of Investigative Dermatology 2013

Epidermal nerve fibers modulate keratinocyte growth via neuropeptide signaling in an innervated skin model

Roggenkamp D, Köpnick S, Stäb F, Wenck H, Schmelz M, Neufang G.

Methods in Molecular Biology 2013

Quantification of cyclobutane pyrimidine dimers in human epidermal stem cells

Ruetze M, Gallinat S, Wenck H, Knott A.

Journal of Dermatological Science 2013

A novel niche for skin derived precursors in non-follicular skin

Ruetze M, Knauer T, Gallinat S, Wenck H, Achterberg V, Maerz A, Deppert W, Knott A.

International Journal of Cosmetic Science 2013

Efficient sweat reduction of three different antiperspirant application forms during stress-induced sweating

Schmidt-Rose T, Lehmbeck F, Bürger A, Windisch B, Keyhani R, Max H.

Skin Pharmacology and Physiology 2013

Efficacy of a new tonic containing urea, lactate, polidocanol, and glycyrrhiza inflata root extract in the treatment of a dry, itchy, and subclinically inflamed scalp

Schweiger D, Baufeld C, Drescher P, Oltrogge B, Höpfner S, Mess A, Lüttke J, Rippke F, Filbry A, Max H.

Biotechnology Journal 2013

A tissue-engineered human dermal construct utilizing fibroblasts and transforming growth factor β1 to promote elastogenesis

Sommer N, Sattler M, Weise JM, Wenck H, Gallinat S, Fischer F.

Journal of Dermatological Science 2013

UV-mediated downregulation of the endocytic collagen receptor, Endo180, contributes to accumulation of extracellular collagen fragments in photoaged skin

Tang S, Lucius R, Wenck H, Gallinat S, Weise JM.

2012

Angiogenesis 2012

DNA methylation regulates lineage-specifying genes in primary lymphatic and blood endothelial cells

Brönneke S, Brückner B, Peters N, Bosch TC, Stäb F, Wenck H, Hagemann S, Winnefeld M.

Analytical and Bioanalytical Chemistry 2012

Improved sample preparation for MALDI-MSI of endogenous compounds in skin tissue sections and mapping of exogenous active compounds subsequent to ex-vivo skin penetration

Enthaler B, Pruns JK, Wessel S, Rapp C, Fischer M, Wittern KP.

Journal of Dermatological Science 2012

Poly(A) tail shortening correlates with mRNA repression in tropoelastin regulation

Hagmeister U, Reuschlein K, März A, Wenck H, Gallinat S, Lucius R, Knott A.

Journal of Investigative Dermatology 2012

How much sun protection is needed?: Are we on the way to full-spectrum protection?

Kolbe L.

Skin Research & Technology 2012

Impact of collagen crosslinking on the second harmonic generation signal and the fluorescence lifetime of collagen autofluorescence

Lutz V, Sattler M, Gallinat S, Wenck H, Poertner R, Fischer F.

International Journal of Cosmetic Science 2012

Characterization of fibrillar collagen types using multi-dimensional multiphoton laser scanning microscopy

Lutz V, Sattler M, Gallinat S, Wenck H, Poertner R, Fischer F.

Experimental Dermatology 2012

UV radiation induces the release of angiopoietin-2 from dermal microvascular endothelial cells

Navid F, Kolbe L, Stäb F, Korff T, Neufang G.

Journal of Cosmetic Dermatology 2012

Topically applied L-carnitine effectively reduces sebum secretion in human skin

Peirano RI, Hamann T, Düsing HJ, Akhiani M, Koop U, Schmidt-Rose T, Wenck H.

Journal of Biomedical Optics 2012

Approach to quantify human dermal skin aging using multiphoton laser scanning microscopy

Puschmann S, Rahn CD, Wenck H, Gallinat S, Fischer F.

Journal of Investigative Dermatology 2012

Atopic keratinocytes induce increased neurite outgrowth in a coculture model of porcine dorsal root ganglia neurons and human skin cells

Roggenkamp D, Falkner S, Stäb F, Petersen M, Schmelz M, Neufang G.

Skin Pharmacology and Physiology 2012

Effects of glyceryl glucoside on AQP3 expression, barrier function and hydration of human skin

Schrader A, Siefken W, Kueper T, Breitenbach U, Gatermann C, Sperling G, Biernoth T, Scherner C, Stäb F, Wenck H, Wittern KP, Blatt T.

PLOS One 2012

Identification of new genes involved in human adipogenesis and fat storage

Söhle J, Machuy N, Smailbegovic E, Holtzmann U, Grönniger E, Wenck H, Stäb F, Winnefeld M.

Proceedings of the National Academy of Sciences of the United States of America 2012

Krüppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes

Spörl F, Korge S, Jürchott K, Wunderskirchner M, Schellenberg K, Heins S, Specht A, Stoll C, Klemz R, Maier B, Wenck H, Schrader A, Kunz D, Blatt T, Kramer A.

International Journal of Cosmetic Science 2012

Investigation of friction and perceived skin feel after application of suspensions of various cosmetic powders

Timm K, Myant C, Nuguid H, Spikes HA, Grunze M.

2011

Biofactors 2011

Biochemical rationale and experimental data on the antiaging properties of CoQ(10) at skin level

Blatt T, Littarru GP.

Journal of Cosmetic Dermatology 2011

Folic acid and creatine improve the firmness of human skin in vivo

Fischer F, Achterberg V, März A, Puschmann S, Rahn CD, Lutz V, Krüger A, Schwengler H, Jaspers S, Koop U, Blatt T, Wenck H, Gallinat S.

Journal of Investigative Dermatology 2011

A comprehensive analysis of microRNA expression during human keratinocyte differentiation in vitro and in vivo

Hildebrand J, Rütze M, Walz N, Gallinat S, Wenck H, Deppert W, Grundhoff A, Knott A.

PAIN 2011

TRP-channel-specific cutaneous eicosanoid release patterns

Jain A, Brönneke S, Kolbe L, Stäb F, Wenck H, Neufang G.

International Journal of Cosmetic Science 2011

Effective prevention of stress-induced sweating and axillary malodour formation in teenagers

Martin A, Hellhammer J, Hero T, Max H, Schult J, Terstegen L.

Analytical Chemistry 2011

Qualitative analysis of tackifier resins in pressure sensitive adhesives using direct analysis in real time time-of-flight mass spectrometry

Mess A, Vietzke JP, Rapp C, Francke W.

Journal of Cosmetic Dermatology 2011

Dermal penetration of creatine from a face-care formulation containing creatine, guarana and glycerol is linked to effective antiwrinkle and antisagging efficacy in male subjects

Peirano RI, Achterberg V, Düsing HJ, Akhiani M, Koop U, Jaspers S, Krüger A, Schwengler H, Hamann T, Wenck H, Stäb F, Gallinat S, Blatt T.

Toxicology in Vitro 2011

In vitro detection of contact allergens: development of an optimized protocol using human peripheral blood monocyte-derived dendritic cells

Reuter H, Spieker J, Gerlach S, Engels U, Pape W, Kolbe L, Schmucker R, Wenck H, Diembeck W, Wittern KP, Reisinger K, Schepky AG.

Journal of Dermatological Science 2011

Damage at the root of cell renewal--UV sensitivity of human epidermal stem cells

Ruetze M, Dunckelmann K, Schade A, Reuschlein K, Mielke H, Weise JM, Gallinat S, Wenck H, Knott A.

Skin Research & Technology 2011

Qualification of a new and precise automatic tool for the assessment of hair diameters in phototrichograms

Scheede S, Herpens A, Burmeister F, Oltrogge B, Saenger K, Schmidt-Rose T, Schreiner V, Wenck H, Knieps T, Berlage T.

International Journal of Cosmetic Science 2011

Efficacy of a piroctone olamine/climbazol shampoo in comparison with a zinc pyrithione shampoo in subjects with moderate to severe dandruff

Schmidt-Rose T, Braren S, Fölster H, Hillemann T, Oltrogge B, Philipp P, Weets G, Fey S.

Journal of Investigative Dermatology 2011

A circadian clock in HaCaT keratinocytes

Spörl F, Schellenberg K, Blatt T, Wenck H, Wittern KP, Schrader A, Kramer A.

Biointerphases 2011

Cosmetic powder suspensions in compliant, fingerprintlike contacts

Timm K, Myant C, Spikes HA, Schneider M, Ladnorg T, Grunze M.

2010

Contact Dermatitis 2010

Determination of formaldehyde in formaldehyde-releaser patch test preparations

Emeis D, de Groot AC, Brinkmann J.

PLOS Genetics 2010

Aging and chronic sun exposure cause distinct epigenetic changes in human skin

Grönniger E, Weber B, Heil O, Peters N, Stäb F, Wenck H, Korn B, Winnefeld M, Lyko F.

Cell Biology International 2010

A new protocol for functional analysis of adipogenesis using reverse transfection technology and time-lapse video microscopy

Grönniger E, Wessel S, Kühn SC, Söhle J, Wenck H, Stäb F, Winnefeld M.

PLOS One 2010

A novel in vitro method for the detection and characterization of photosensitizers

Karschuk N, Tepe Y, Gerlach S, Pape W, Wenck H, Schmucker R, Wittern KP, Schepky A, Reuter H.

Journal of Colloid and Interface Science 2010

Phase behavior of liquid-crystalline emulsion systems

Kudla P, Sokolowski T, Blümich B, Wittern KP.

Journal of Investigative Dermatology 2010

A functional ABCC11 allele is essential in the biochemical formation of human axillary odor

Martin A, Saathoff M, Kuhn F, Max H, Terstegen L, Natsch A.

Integrative Biology 2010

In situ localization of epidermal stem cells using a novel multi epitope ligand cartography approach

Ruetze M, Gallinat S, Wenck H, Deppert W, Knott A.

Methods in Molecular Biology 2010

Analysis of tissue-specific gene expression using laser capture microdissection

Ruetze M, Lochner K, Gallinat S, Knott A.

Nutrition & Metabolism 2010

Lotus leaf extract and L-carnitine influence different processes during the adipocyte life cycle

Siegner R, Heuser S, Holtzmann U, Söhle J, Schepky A, Raschke T, Stäb F, Wenck H, Winnefeld M.

Journal of Investigative Dermatology 2010

Real-time monitoring of membrane cholesterol reveals new insights into epidermal differentiation

Spörl F, Wunderskirchner M, Ullrich O, Bömke G, Breitenbach U, Blatt T, Wenck H, Wittern KP, Schrader A.

2009

Skin Research & Technology 2009

Validation of the body scanner as a measuring tool for a rapid quantification of body shape

Bretschneider T, Koop U, Schreiner V, Wenck H, Jaspers S.

International Journal of Cosmetic Science 2009

Qualification of a precise and easy-to-handle sweat casting imprint method for the prediction and quantification of anti-perspirant efficacy

Keyhani R, Scheede S, Thielecke I, Wenck H, Schmucker R, Schreiner V, Ennen J, Herpens A.

Biogerontology 2009

Deregulation of versican and elastin binding protein in solar elastosis

Knott A, Reuschlein K, Lucius R, Stäb F, Wenck H, Gallinat S.

Nutrition & Metabolism 2009

White Tea extract induces lipolytic activity and inhibits adipogenesis in human subcutaneous (pre)-adipocytes

Söhle J, Knott A, Holtzmann U, Siegner R, Grönniger E, Schepky A, Gallinat S, Wenck H, Stäb F, Winnefeld M.

Applied Spectroscopy 2009

Fourier transform infrared imaging spectroscopy of the diffusion process of D2O into polyamide 11

Wessel E, Vogel C, Siesler HW.

2008

Journal of Biophotonics 2008

Assessing the risk of skin damage due to femtosecond laser irradiation

Fischer F, Volkmer B, Puschmann S, Greinert R, Breitbart E, Kiefer J, Wepf R.

Journal of Biomedical Optics 2008

Risk estimation of skin damage due to ultrashort pulsed, focused near-infrared laser irradiation at 800 nm

Fischer F, Volkmer B, Puschmann S, Greinert R, Breitbart W, Kiefer J, Wepf R.

Skin Research & Technology 2008

Visualizing nuclei in skin cryosections: viable options to 4'6-diamidino-2-phenylindol for confocal laser microscopy

Gläser K, Wilke K, Wepf R, Biel SS.

Skin Research & Technology 2008

Non-invasive monitoring of oxidative skin stress by ultraweak photon emission measurement. II: biological validation on ultraviolet A-stressed skin

Hagens R, Khabiri F, Schreiner V, Wenck H, Wittern KP, Duchstein HJ, Mei W.

Skin Research & Technology 2008

Non-invasive monitoring of oxidative skin stress by ultraweak photon emission (UPE)-measurement. I: mechanisms of UPE of biological materials

Khabiri F, Hagens R, Smuda C, Soltau A, Schreiner V, Wenck H, Wittern KP, Duchstein HJ, Mei W.

Journal of Cosmetic Dermatology 2008

A novel treatment option for photoaged skin

Knott A, Koop U, Mielke H, Reuschlein K, Peters N, Muhr GM, Lenz H, Wensorra U, Jaspers S, Kolbe L, Raschke T, Stäb F, Wenck H, Gallinat S.

Journal of Cosmetic Dermatology 2008

Natural Arctium lappa fruit extract improves the clinical signs of aging skin

Knott A, Reuschlein K, Mielke H, Wensorra U, Mummert C, Koop U, Kausch M, Kolbe L, Peters N, Stäb F, Wenck H, Gallinat S.

Annals of the New York Academy of Sciences 2008

Modification of vimentin: a general mechanism of nonenzymatic glycation in human skin

Kueper T, Grune T, Muhr GM, Lenz H, Wittern KP, Wenck H, Stäb F, Blatt T.

Biofactors 2008

Aging skin is functionally anaerobic: importance of coenzyme Q10 for anti aging skin care

Prahl S, Kueper T, Biernoth T, Wöhrmann Y, Münster A, Fürstenau M, Schmidt M, Schulze C, Wittern KP, Wenck H, Muhr GM, Blatt T.

Journal of Cosmetic Dermatology 2008

Skin-lightening effects of a new face care product in patients with melasma

Scherdin U, Bürger A, Bielfeldt S, Filbry A, Weber T, Schölermann A, Wigger-Alberti W, Rippke F, Wilhelm KP.

Experimental Dermatology 2008

A strategy for correlative microscopy of large skin samples: towards a holistic view of axillary skin complexity

Wilke K, Wick K, Keil FJ, Wittern KP, Wepf R, Biel SS.

Pigment Cell & Melanoma Research 2008

Pigmentation effects of solar-simulated radiation as compared with UVA and UVB radiation

Wolber R, Schlenz K, Wakamatsu K, Smuda C, Nakanishi Y, Hearing VJ, Ito S.

2007

Journal of colloid and interface science 2007

Ultrasonic velocity measurements as a method for investigating phase transitions of monoglyceride emulsifier systems in pearlescent cosmetic creams

Alberola C, Dederichs T, Emeis D, Möller M, Sokolowski T, Wittern KP.

Analytical Chemistry 2007

Quantitative 13C NMR spectroscopic studies on the equilibrium of formaldehyde with its releasing cosmetic preservatives

Emeis D, Anker W, Wittern KP.

International Journal of Cosmetic Science 2007

Contact angle measurement - a reliable supportive method for screening water-resistance of ultraviolet-protecting products in vivo

Hagens R, Mann T, Schreiner V, Barlag HG, Wenck H, Wittern KP, Mei W.

Molecular and Cellular Biochemistry 2007

Inhibition of cytosolic and mitochondrial creatine kinase by siRNA in HaCaT- and HeLaS3-cells affects cell viability and mitochondrial morphology

Lenz H, Schmidt M, Welge V, Kueper T, Schlattner U, Wallimann T, Elsässer HP, Wittern KP, Wenck H, Staeb F, Blatt T.

Biogerontology 2007

Expression of decorin and collagens I and III in different layers of human skin in vivo: a laser capture microdissection study

Lochner K, Gaemlich A, Südel KM, Venzke K, Moll I, Knott A, Stäb F, Wenck H, Döring O, Böttger M, Gallinat S.

International Journal of Cosmetic Science 2007

A short history of sweat gland biology

Wilke K, Martin A, Terstegen L, Biel SS.

2006

Archives of Dermatological Research 2006

Anti-inflammatory efficacy of Licochalcone A: correlation of clinical potency and in vitro effects

Kolbe L, Immeyer J, Batzer J, Wensorra U, tom Dieck K, Mundt C, Wolber R, Stäb F, Schönrock U, Ceilley RI, Wenck H.

International Journal of Cosmetic Science 2006

Study on the transferability of the time temperature superposition principle to emulsions

Muehlbach M, Brummer R, Eggers R.

Skin Research & Technology 2006

Mid-infrared spectroscopy on skin using a silver halide fibre probe in vivo

Ring A, Schreiner V, Wenck H, Wittern KP, Küpper L, Keyhani R.

Journal of Cosmetic Dermatology 2006

Skin tolerance, efficacy, and quality of life of patients with red facial skin using a skin care regimen containing Licochalcone A

Weber TM, Ceilley RI, Buerger A, Kolbe L, Trookman NS, Rizer RL, Schoelermann A.

Applied Spectroscopy 2006

Observation of a penetration depth gradient in attenuated total reflection fourier transform infrared spectroscopic imaging applications

Wessel E, Heinsohn G, Schmidt-Lewerkuehne H, Wittern KP, Rapp C, Siesler HW.

Skin Pharmacology and Physiology 2006

Are sweat glands an alternate penetration pathway? Understanding the morphological complexity of the axillary sweat gland apparatus

Wilke K, Wepf R, Keil FJ, Wittern KP, Wenck H, Biel SS.

2005

Biofactors 2005

Stimulation of skin's energy metabolism provides multiple benefits for mature human skin

Blatt T, Lenz H, Koop U, Jaspers S, Weber T, Mummert C, Wittern KP, Stäb F, Wenck H.

Alternatives to Laboratory Animals 2005

Skin absorption and penetration

Diembeck W, Eskes C, Heylings JR, Langley G, Rogiers V, van de Sandt JJ, Zuang V.

Journal of Biomedical Optics 2005

Noninvasive measurement of cell volume changes by negative staining

Droste MS, Biel SS, Terstegen L, Wittern KP, Wenck H, Wepf R.

Photochemistry and Photobiology 2005

Novel aspects of intrinsic and extrinsic aging of human skin: beneficial effects of soy extract

Südel KM, Venzke K, Mielke H, Breitenbach U, Mundt C, Jaspers S, Koop U, Sauermann K, Knussman-Hartig E, Moll I, Gercken G, Young AR, Stäb F, Wenck H, Gallinat S.

Analytical and Bioanalytical Chemistry 2005

Quantitative determination of cationic modified polysaccharides on hair using LC-MS and LC-MS-MS

Ungewiss J, Vietzke JP, Rapp C, Schmidt-Lewerkühne H, Wittern KP, Salzer R.

2004

Clinical Chemistry 2004

Detection of human polyomaviruses in urine from bone marrow transplant patients: comparison of electron microscopy with PCR

Biel SS, Nitsche A, Kurth A, Siegert W, Ozel M, Gelderblom HR.

International Journal of Cosmetic Science 2004

Dielectric spectroscopy of concentrated cosmetic W/O-emulsions: possibilities to distinguish product changes caused by coalescence, sedimentation and variation of ingredients

Friedrich S, Brummer R, Wittern KP, Hochstein B.

Skin Pharmacology and Physiology 2004

Topical activity of ascorbic acid: from in vitro optimization to in vivo efficacy

Raschke T, Koop U, Düsing HJ, Filbry A, Sauermann K, Jaspers S, Wenck H, Wittern KP.

Skin Pharmacology and Physiology 2004

Dead but highly dynamic--the stratum corneum is divided into three hydration zones

Richter T, Peuckert C, Sattler M, Koenig K, Riemann I, Hintze U, Wittern KP, Wiesendanger R, Wepf R.

American Journal of Clinical Dermatology 2004

Stratum corneum pH in atopic dermatitis: impact on skin barrier function and colonization with Staphylococcus Aureus

Rippke F, Schreiner V, Doering T, Maibach HI.

BMC Dermatology 2004

Topically applied vitamin C increases the density of dermal papillae in aged human skin

Sauermann K, Jaspers S, Koop U, Wenck H.

International Journal of Cosmetic Science 2004

Influence of cleansing on stratum corneum tryptic enzyme in human skin

Schepky AG, Holtzmann U, Siegner R, Zirpins S, Schmucker R, Wenck H, Wittern KP, Biel SS.

International Journal of Cosmetic Science 2004

In vivo assessment of the efficacy of an innovative face care system in subjects with mild acne vulgaris

Scherdin U, Presto S, Rippke F, Nielsen J, Strassner M, Imadojemun A, Gärtner E, Herpens A, Korting HC, Bielfeldt S.

Journal der Deutschen Dermatologischen Gesellschaft 2004

[Alpha-glucosylrutin, a highly effective flavonoid for protection against oxidative stress]

Wolber R, Stäb F, Max H, Wehmeyer A, Hadshiew I, Wenck H, Rippke F, Wittern KP.

2003

Journal of Microscopy 2003

From tissue to cellular ultrastructure: closing the gap between micro- and nanostructural imaging

Biel SS, Kawaschinski K, Wittern KP, Hintze U, Wepf R.

Journal of Colloid and Interface Science 2003

Adsorption kinetics of surfactant mixtures from micellar solutions as studied by maximum bubble pressure technique

Frese Ch, Ruppert S, Sugár M, Schmidt-Lewerkühne H, Wittern KP, Fainerman VB, Eggers R, Miller R.

Journal of Investigative Dermatology 2003

Role of taurine accumulation in keratinocyte hydration

Janeke G, Siefken W, Carstensen S, Springmann G, Bleck O, Steinhart H, Höger P, Wittern KP, Wenck H, Stäb F, Sauermann G, Schreiner V, Doering T.

Photochemistry and Photobiology 2003

Tight control of matrix metalloproteinase-1 activity in human skin

Südel KM, Venzke K, Knussmann-Hartig E, Moll I, Stäb F, Wenck H, Wittern KP, Gercken G, Gallinat S.

Photodermatology Photoimmunology and Photomedicine 2003

The influence of pre-irradiation on the predictability of in vivo UVA protection with a new in vitro method

Wendel V, Klette E, Wittern KP, Gers-Barlag H.

2002

Skin Pharmacology and Applied Skin Physiology 2002

Comparison of activities dependent on glutathione S-transferase and cytochrome P-450 IA1 in cultured keratinocytes and reconstructed epidermal models

Harris IR, Siefken W, Beck-Oldach K, Brandt M, Wittern KP, Pollet D.

Skin Pharmacology and Applied Skin Physiology 2002

NAD(P)H:quinone reductase activity in human epidermal keratinocytes and reconstructed epidermal models

Harris IR, Siefken W, Beck-Oldach K, Wittern KP, Pollet D.

International Journal of Cosmetic Science 2002

A quick, practical test procedure to evaluate the performance of instruments used for in vitro UV protection measurements

Klette E, Wendel V, Wittern KP, Gers-Barlag H.

Rapid Communications in Mass Spectrometry 2002

Characterization of low molecular weight hydrocarbon oligomers by laser desorption/ionization time-of-flight mass spectrometry using a solvent-free sample preparation method

Pruns JK, Vietzke JP, Strassner M, Rapp C, Hintze U, König WA.

American Journal of Clinical Dermatology 2002

The acidic milieu of the horny layer: new findings on the physiology and pathophysiology of skin pH

Rippke F, Schreiner V, Schwanitz HJ.

Skin Research & Technology 2002

Age related changes of human skin investigated with histometric measurements by confocal laser scanning microscopy in vivo

Sauermann K, Clemann S, Jaspers S, Gambichler T, Altmeyer P, Hoffmann K, Ennen J.

BMC Dermatology 2002

Histometric data obtained by in vivo confocal laser scanning microscopy in patients with systemic sclerosis

Sauermann K, Gambichler T, Jaspers S, Radenhausen M, Rapp S, Reich S, Altmeyer P, Clemann S, Teichmann S, Ennen J, Hoffmann K.

Skin Research & Technology 2002

Investigation of basal cell carcinoma [correction of carcionoma] by confocal laser scanning microscopy in vivo

Sauermann K, Gambichler T, Wilmert M, Rotterdam S, Stücker M, Altmeyer P, Hoffmann K.

Advanced Drug Delivery Reviews 2002

Distribution of sunscreens on skin

Schulz J, Hohenberg H, Pflücker F, Gärtner E, Will T, Pfeiffer S, Wepf R, Wendel V, Gers-Barlag H, Wittern KP.

2001

Journal of Clinical Virology 2001

Diagnostic virology--the need for electron microscopy: a discussion paper

Biel SS, Madeley D.

Journal of Investigative Dermatology 2001

In human keratinocytes the Common Deletion reflects donor variabilities rather than chronologic aging and can be induced by ultraviolet A irradiation

Koch H, Wittern KP, Bergemann J.

Photochemistry and Photobiology 2001

Induction of mRNA for matrix metalloproteinase 1 and tissue inhibitor of metalloproteinases 1 in human skin in vivo by solar simulated radiation

Lahmann C, Young AR, Wittern KP, Bergemann J.

International Journal of Cosmetic Science 2001

In vitro testing to assess the UVA protection performance of sun care products

Members of the DGK (German Society for Scientific and Applied Cosmetics) Task Force ‘Sun Protection’; Gers-Barlag H, Klette E, Bimczok R, Springob C, Finkel P, Rudolph T, Gonzenbach HU, Schneider PH, Kockott D, Heinrich U, Tronnier H, Bernklau R, Johncock W, Langner R, Driller HJ, Westenfelder H.

Journal of Dermatological Treatment 2001

Results of photoprovocation and field studies on the efficacy of a novel topically applied antioxidant in polymorphous light eruption

Rippke F, Wendt G, Bohnsack K, Dörschner A, Stäb F, Hölzle E, Moll I.

Journal of Investigative Dermatology 2001

Localization of ceramide and glucosylceramide in human epidermis by immunogold electron microscopy

Vielhaber G, Pfeiffer S, Brade L, Lindner B, Goldmann T, Vollmer E, Hintze U, Wittern KP, Wepf R.

Lipids 2001

Comparative investigation of human stratum corneum ceramides

Vietzke JP, Brandt O, Abeck D, Rapp C, Strassner M, Schreiner V, Hintze U.

Journal of Investigative Dermatology 2001

Selective pick-up of increased iron by deferoxamine-coupled cellulose abrogates the iron-driven induction of matrix-degrading metalloproteinase 1 and lipid peroxidation in human dermal fibroblasts in vitro: a new dressing concept

Wenk J, Foitzik A, Achterberg V, Sabiwalsky A, Dissemond J, Meewes C, Reitz A, Brenneisen P, Wlaschek M, Meyer-Ingold W, Scharffetter-Kochanek K.

2000

Inflammation Research 2000

Comparative quantification of IL-1beta, IL-10, IL-10r, TNFalpha and IL-7 mRNA levels in UV-irradiated human skin in vivo

Brink N, Szamel M, Young AR, Wittern KP, Bergemann J.

Journal of Investigative Dermatology 2000

Regulation of HMG-CoA synthase and HMG-CoA reductase by insulin and epidermal growth factor in HaCaT keratinocytes

Harris IR, Höppner H, Siefken W, Farrell AM, Wittern KP.

Journal of Microscopy 2000

Penetration pathways of fluorescent dyes in human hair fibres investigated by scanning near-field optical microscopy

Kelch A, Wessel S, Will T, Hintze U, Wepf R, Wiesendanger R.

Journal of Investigative Dermatology 2000

High-pressure freezing provides new information on human epidermis: simultaneous protein antigen and lamellar lipid structure preservation. Study on human epidermis by cryoimmobilization

Pfeiffer S, Vielhaber G, Vietzke JP, Wittern KP, Hintze U, Wepf R.

Journal of Investigative Dermatology 2000

Barrier characteristics of different human skin types investigated with X-ray diffraction, lipid analysis, and electron microscopy imaging

Schreiner V, Gooris GS, Pfeiffer S, Lanzendörfer G, Wenck H, Diembeck W, Proksch E, Bouwstra J.

Experimental Dermatology 2000

Regulation of cholesterol synthesis by oleic and palmitic acid in keratinocytes

Siefken W, Höppner H, Harris IR.

Methods in Enzymology 2000

Topically applied antioxidants in skin protection

Stäb F, Wolber R, Blatt T, Keyhani R, Sauermann G.

Skin Research and Technology 2000

Axillary pH and influence of deodorants

Stenzaly-Achtert S, Schölermann A, Schreiber J, Diec KH, Rippke F, Bielfeldt S.

Photochemistry and Photobiology 2000

P53-dependent UVB responsiveness of human keratinocytes can be altered by cultivation on cell cycle-arrested dermal fibroblasts

Will K, Neben M, Schmidt-Rose T, Deppert W, Wittern KP, Bergemann J.

1999

Zeitschrift für Gerontologie und Geriatrie 1999

[Modulation of oxidative stresses in human aging skin]

Blatt T, Mundt C, Mummert C, Maksiuk T, Wolber R, Keyhani R, Schreiner V, Hoppe U, Schachtschabel DO, Stäb F.

Food and Chemical Toxicology 1999

Test guidelines for in vitro assessment of dermal absorption and percutaneous penetration of cosmetic ingredients. European Cosmetic, Toiletry and Perfumery Association

Diembeck W, Beck H, Benech-Kieffer F, Courtellemont P, Dupuis J, Lovell W, Paye M, Spengler J, Steiling W.

BioFactors 1999

Coenzyme Q10, a cutaneous antioxidant and energizer

Hoppe U, Bergemann J, Diembeck W, Ennen J, Gohla S, Harris I, Jacob J, Kielholz J, Mei W, Pollet D, Schachtschabel D, Sauermann G, Schreiner V, Stäb F, Steckel F.

Toxicology in Vitro 1999

COLIPA validation project on in vitro eye irritation tests for cosmetic ingredients and finished products (phase I): the red blood cell test for the estimation of acute eye irritation potentials. Present status

Pape WJ, Pfannenbecker U, Argembeaux H, Bracher M, Esdaile DJ, Hagino S, Kasai Y, Lewis RW.

International Journal of Cosmetic Science 1999

The Outermost Stratum Corneum Layer is an Effective Barrier Against Dermal Uptake of Topically Applied Micronized Titanium Dioxide

Pflücker F, Hohenberg H, Hölzle E, Will T, Pfeiffer S, Wepf R, Diembeck W, Wenck H, Gers-Barlag H.

Alternatives to Laboratory Animals 1999

The Potential Use of Non-invasive Methods in the Safety Assessment of Cosmetic Products

Rogiers V, Balls M, Basketter D, Berardesca E, Edwards C, Elsner P, Ennen J, Lévêque JL, Lóden M, Masson P, Parra J, Paye M, Piérard G, Rodrigues L, Schaefer H, Salter D, Zuang V.

Journal of Photochemistry and Photobiology B: Biology 1999

Analysis of UV-B-induced DNA damage and its repair in heat-shocked skin cells

Schmidt-Rose T, Pollet D, Will K, Bergemann J, Wittern KP.

BioTechniques 1999

Semiquantitative chemiluminescent detection of UV-B-induced point mutations in the p53 tumor-suppressor gene

Siefken W, Hoppe U, Bergemann J.

Biochimica et Biophysica Acta 1999

Hydration of human nails investigated by NIR-FT-Raman spectroscopy

Wessel S, Gniadecka M, Jemec GB, Wulf HC.

1998

Alternatives to Laboratory Animals 1998

Report on the COLIPA Workshop on Mechanisms of Eye Irritation

Bruner LH, de Silva O, Earl LK, Easty DL, Pape W, Spielmann H.

Skin Research & Technology 1998

Assessment of the atrophogenicity of corticosteroids to human skin using non-invasive methods

Kolbe L, Stoudemayer T, Kligman AM.

Mutation Research 1998

Kinetics of DNA strand breaks and protection by antioxidants in UVA- or UVB-irradiated HaCaT keratinocytes using the single cell gel electrophoresis assay

Lehmann J, Pollet D, Peker S, Steinkraus V, Hoppe U.

European Journal of Pharmaceutics and Biopharmaceutics 1998

Comparison between a twin-screw extruder and a rotary ring die press. Part II: influence of process variables

Schmidt C, Kleinebudde P.

Alternatives to Laboratory Animals 1998

A Study on UV Filter Chemicals from Annex VII of European Union Directive 76/768/EEC, in the In Vitro 3T3 NRU Phototoxicity Test

Spielmann H, Balls M, Dupuis J, Pape WJ, de Silva O, Holzhütter HG, Gerberick F, Liebsch M, Lovell WW, Pfannenbecker U.

1997

Toxicology in Vitro 1997

In vitro model for contact sensitization: I. Stimulatory capacities of human blood-derived dendritic cells and their phenotypical alterations in the presence of contact sensitizers

Degwert J, Steckel F, Hoppe U, Kligman LH.

Applied Toxicology: Approaches Through Basic Science 1997

Validation of in vitro methods to single out photoirritants using mechanistically based tests

Pape WJ.

Toxicology in Vitro 1997

In vitro model for contact sensitization: II. Induction of IL-1beta mRNA in human blood-derived dendritic cells by contact sensitizers

Reutter K, Jäger D, Degwert J, Hoppe U.

Inflammation Research 1997

Simultaneous HPLC determination of metabolites of the inflammatory cascade

Schepky AG, Siegner R, Diembeck W.

1996

Journal of Wound Care 1996

Hydroactive dressings and serum proteins: an in vitro study

Achterberg V, Welling C, Meyer-Lngold W.

Skin Research and Technology 1996

Non-invasive cosmetic efficacy testing in human volunteers: some general principles

Salter D.

International Journal of Cosmetic Science 1996

Consequences for sun protection factors when solar simulator spectra deviate from the spectrum of the sun

Uhlmann B, Mann T, Gers-Barlag H, Alert D, Sauermann G.

1995

Advances In Experimental Medicine and Biology 1995

Antigen presenting and primary in vitro sensitizing capacity of CD1a+ dendritic cells generated from human blood

Degwert J, Steckel F, Hoppe U.

Cell Biology International 1995

Platelet-derived growth factor

Meyer-Ingold W, Eichner W.

Advances In Experimental Medicine and Biology 1995

Phenotype and alloactivating capacity of dendritic cells generated under different culture conditions from human peripheral blood

Steckel F, Degwert J, Hoppe U.

1994

Toxicology in Vitro 1994

In vitro analysis of immunoprotective effects of topical sunscreens

Degwert J, Pape W, Hoppe U.

Toxicology in Vitro 1994

Combined in vitro assay for photohaemolysis and haemoglobin oxidation as part of a phototoxicity test system assessed with various phototoxic substances

Pape WJ, Brandt M, Pfannenbecker U.

Toxicology in Vitro 1994

Differentiation of monocytes in vitro: Influence of different types of substances

Steckel F, Pape W, Hoppe U.

1993

Trends in Biotechnology 1993

Wound therapy: growth factors as agents to promote healing

Meyer-Ingold W.

Toxicology in Vitro 1993

Immunocompetent cells for in vitro screening of skin irritation

Pape WJ, Degwert J, Steckel F, Hoppe U.

1992

Journal of Pharmaceutical and Biomedical Analysis 1992

Determination of moxonidine (BDF 5895) in plasma by gas chromatography-negative ion chemical ionization mass spectrometry

Rudolph M, Janssen W, Strassner M.

International Journal of Cosmetic Science 1992

The determination of the antiperspirant activity of aluminium-chlorhydrate by digital image-analysis

Sauermann G, Hoppe U, Kligman AM.

1991

Skin Pharmacology 1991

In vitro methods for the assessment of primary local effects of topically applied preparations

Pape WJ, Hoppe U.

1990

Arzneimittelforschung 1990

Standardization of an in vitro red blood cell test for evaluating the acute cytotoxic potential of tensides

Pape WJ, Hoppe U.

Journal of Chromatography 1990

Determination of saterinone enantiomers in plasma samples with an internal standard using a Chiralcel OD column, fractionation and reversed-phase chromatography

Rudolph M, Volk D, Schmiedel G.

1990

Direct enantiomeric separation of saterinone by high-performance liquid chromatography

Rudolph M.

1989

Journal of Chromatography 1989

Determination of saterinone in plasma by high-performance liquid chromatography

Rudolph M.

1987

Molecular Toxicology 1987

Validation of the red blood cell test system as in vitro assay for the rapid screening of irritation potential of surfactants

Pape WJ, Pfannenbecker U, Hoppe U.

The Journal of Clinical Pharmacology 1987

Comparison of moxonidine and clonidine HCl in treating patients with hypertension

Plänitz V.

Loaded Results